Obesity and Metabolic Disorders

Obesity, Cancer Risk, and Chronic Disease Associations

Excess adiposity contributes to increased risks of multiple cancers, including breast, colorectal, pancreatic, and endometrial cancers, through mechanisms involving insulin resistance, chronic inflammation, and hormonal dysregulation. Obesity also accelerates the onset of other chronic diseases, including osteoarthritis, sleep apnea, and renal dysfunction. Understanding the molecular and systemic links between obesity and chronic disease is critical for designing preventive and therapeutic strategies. Integrative care approaches and population-based interventions are necessary to mitigate the broad health impacts of obesity across diverse patient populations.